Please use this identifier to cite or link to this item: http://guaiaca.ufpel.edu.br:8080/handle/123456789/738
metadata.dc.type: Article
Title: Preparation, modification, and characterization of alginate hydrogel with nano-/microfibers: a new perspective for tissue engineering
Authors: Santana, Bianca Palma
Nedel, Fernanda
Piva, Evandro
Carvalho, Rodrigo Varella de
Demarco, Flávio Fernando
Carreño, Neftali Lenin Villarreal
Abstract: We aimed to develop an alginate hydrogel (AH) modified with nano-/microfibers of titanium dioxide (nfTD) and hydroxyapatite(nfHY) and evaluated its biological and chemical properties. Nano-/microfibers of nfTD and nfHY were combined with AH, and its chemical properties were evaluated by FTIR spectroscopy, X-ray diffraction, energy dispersive X-Ray analysis, and the cytocompatibility by the WST-1 assay. The results demonstrate that the association of nfTD and nfHY nano-/microfibers to AH did notmodified the chemical characteristics of the scaffold and that the association was not cytotoxic. In the first 3 h of culture with NIH/3T3 cells nfHY AH scaffolds showed a slight increase in cell viability when compared to AH alone or associated with nfTD. However, an increase in cell viability was observed in 24 h when nfTD was associated with AH scaffold. In conclusion our study demonstrates that the combination of nfHY and nfTD nano-/microfibers in AH scaffold maintains the chemical characteristics of alginate and that this association is cytocompatible. Additionally the combination of nfHY with AH favored cell viability in a short term, and the addition of nfTD increased cell viability in a long term.
Keywords: Dióxido de titânio
Hidroxiapatita
Espectroscopia
Publisher: Hindawi Publishing Corporation
Citation: CARREÑO, Neftalí Lenin Villarreal ; Evandro Piva ; Carreño, Neftalí L. V. ; SANTANA, B. P. ; Fernanda Nedel ; Carvalho RV ; Demarco F. F. . Preparation, Modification, and Characterization of Alginate Hydrogel with Nano-/Microfibers: A New Perspective for Tissue Engineering. BioMed Research International, v. 2013, p. 1-6, 2013.
URI: http://hdl.handle.net/123456789/738
Issue Date: 2013
Appears in Collections:Departamento de Odontologia Restauradora: Artigos de periódicos

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