Microrganismos de lesões cutâneas de pequenos animais: Resistência a antimicrobianos e bioprospecção de extratos de plantas da família Lamiaceae e Fabaceae

Abstract

Sporotrichosis is a subcutaneous mycosis affecting humans and animals and is caused by Sporothrix complex of fungi, including species S. brasiliensis. Itraconazoleis considered the drug of choice for treatment, but some fungal species have shown greater resistance to this antifungal. In this context, has sought new treatments, especially research on medicinal plants. This work aimed to evaluate the antifungal activity of hydroalcoholic extract of Bauhinia forficata against isolates of Sporothrix brasiliensis. The broth microdilution technique was used to evaluate sensitivity seven fungal isolates (n = 1 canine and n = 6 feline) against ten extract concentrations (100 to 0,19 mg/mL) , using as a positive control itraconazole (0,5 - 64 mg/mL). The concentrations studied was observed MIC of 100 mg / mL of alcoholic extract of B. forficata against S. brasiliensis, but the CFM values were greater than 100 mg / mL for all isolates. Regarding itraconazole, five isolates (71,4 %) showed 64 CFM/mL. Further studies on the plant activity using other forms of extracts, different concentrations and other plant parts must be carried out, as it has activity against other microorganisms, including fungi and could be a good target for study in the treatment of sporotrichosis.