Glicerol como Solvente Reciclável na Preparação de Selenetos Vinílicos

Abstract

In this work, it was developed a new cleaner synthetic methodology for the preparation of vinyl selenides of configuration E and Z 3a-o through vinyl nucleophilic substitution reaction using copper iodide as a catalyst, zinc dust as additive and glycerin as recicable solvent. The products were obtained in good to excellent yelds. After determining the best reaction conditions, we apply this condition at different vinyl bromides and diaryl diselenides substituted with electron donating or electron withdrawing groups. Through this methodology it was possible to prepare a vinyl telluride 3p trans configuration, without alterations in the optimized condition. The reuse system glicerol/Cul/Zn was performed by four cycles providing selenide in satisfactory yelds.