Estudo epidemiológico, classificação histológica, e fatores prognósticos pela técnica de quantificação das AgNORs em tumores mamários felinos

Abstract

In order to study the feline mammary tumors and to seek methods that allow a more objective and reliable, we performed a retrospective analysis of neoplasms in cats from biopsies and autopsies sent to the Regional Diagnostic Laboratory (LRD) of the Federal University of Pelotas (UFPel) in the period 1979 to 2007. From this review there was an epidemiological study based on data from 55 breast neoplasms diagnosed in this period. The tumors were classified according to the histological description for feline mammary tumors. Were used for this criteria presented by Misdorp (2002) supported by WHO/AFIP. For the descriptive histological classification were the following: Three simple adenomas, seven amendments fibroadenomatous and forty-five malignant tumors. Already the histological grading was established according to the system of Elston & Ellis (1991). The graduation was held in feline mammary carcinomas which totaled 45 samples recovered. Being 26 classified I eat degree II , followed for 13 of degree I & for last 6 of degree III. The targets of the present I study have been comparing the efficiency of two methods of classification histological about to these tumors : the histology descriptive and the gradation histological, and again verify factors prognosis of carcinomas feline by technique of quantification of AgNORs breast tumors in cat. Most of these were classified as grade II, followed by grade I and grade III finally. The objective was to further investigate the relationship of these two methods of classification with the AgNOR indices. There was an average of 5.34 AgNOR/nucleus (range 2.06 to 7.88). The counting of AgNOR was evaluated considering the histological grading system. Comparisons were made between the values of AgNOR/nucleus by non-parametric test of Kruskal-Wallis for independent samples. It is concluded that the two classification systems are complementary, but the histological grading provides more detailed information on the possible biological behavior of these neoplasms, and that the mean AgNOR/nucleus tends to increase in tumors that show histological features of malignancy.