Avaliação da sistemática de classificação e graduação de neoplasmas mesenquimais em cães

Abstract

Mesenchymal tumors are a heterogeneous group of tumors originating from mesenchymal cells, with similar clinicopathological characteristics. They occur in any anatomical location, being more common in cutaneous and subcutaneous tissues. Among mesenchymal tumors, the group of Soft Tissue Sarcomas (STMs) stands out. STMs are malignant mesenchymal neoplasms derived from soft connective tissues. There are different proposals regarding which mesenchymal neoplasms are, in fact, part of the group of STMs. Therefore, the objective of this work was to evaluate two systematic classifications of STMs, which include different types of mesenchymal tumors, and determine which one performs the best grouping, aiming at uniformity of the tumors for prognostic purposes. The results are presented in the format of a scientific article. Additionally, we present a second article on soft tissue sarcoma (rhabdomyosarcoma) grade III in dogs. As a methodology for the first article, a retrospective study was carried out on cases of mesenchymal tumors diagnosed in SOVet-UFPel, from 2016 to 2023, where mesenchymal tumors were categorized and grouped according to the classifications proposed by Dennis et al. (2011) and by Hendrick et al. (2017) and it was also verified how long after the diagnosis of STMS, deaths occurred. The Statistics Kingdom© website was used to create Kaplan Meier curves as a parameter to evaluate the groupings made. The STMs according to the classification of Hendrick et al. (2017) and that of Dennis et al, (2011), represented 46.1% and 21.2% of the sample, respectively. In both classifications, STMs affected more elderly female dogs, of a defined large breed. Survival varied according to the methodology used and the tumor type, between 2 and 8 months. It is therefore concluded that further studies are needed regarding the MTS classification systems as well as the feasibility of applying grading systems.