Avaliação da expressão da proteína NOD 1 no líquen plano oral

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells that affects the oral mucosa. It is estimated that the disease affects about 1 to 2% of the adult general population, with a preference for women. Their etiopathogenic mechanism is unclear, four theories exist for the development, probably being connected to an immune response of cellular origin. In 2003 Toll protein was identified as a key regulator of the innate immune system in insects, identified in human homologous proteins, being the Receptor-Binding Domain Nucleotide and Oligomerization - NOD (NLR) the most representative protein studied. The NOD1 protein was found in the epithelium of normal mucosa, whereas TLR2 and TLR4 have been identified with increased expression in OLP. Also, have linked mutations in NOD1 proteins with the development of systemic diseases. The aim of this study was to identify the marking NOD1 protein by immunohistochemistry in oral lichen planus lesions and healthy oral mucosa fragments. Four fields near the epithelial cells located in the inflammatory infiltrate in band and four fields just below the same on each slide were counted. The antibody used marked plasma cells, with statistically greater number of these cells marked in painful biopsies and more development time, and lower in the striae type injuries. In the upper and lower fields, there was significantly higher mark in the test group compared to the control . The results suggest that there are differences in the marking of the antibody in patients with OLP and controls, where the plasma cell count tends to increase with disease progression in painful and smaller lesions in striatal lesions .