Estratégias farmacêuticas com fósforo orgânico e vitamina B12 para melhorar a funcionalidade hepática de vacas leiteiras primíparas após o parto

Abstract

The objective of this study was to evaluate the effects of organic phosphorus (butafosfan) and vitamin B12 (cyanocobalamin) on markers of energy, mineral and inflammatory metabolism, milk production and the liver functionality index of primiparous dairy cows. Twenty-three Holstein dairy cows were randomly allocated into three groups: Catosal (CAT, n = 8), receiving total of 100 mL of Catosal®; Butafosfan (BUT, n = 8) that received a total of 100 mL of aqueous Butafosfan; and Control (CTL, n = 7), receiving total of 100 mL of 0.9% saline. All the animals received the 100 mL divided in five 20 mL applications at 24-hour intervals, subcutaneously, beginning soon after birth. The animals in the group BUT showed lower beta-hydroxybutyrate concentrations (P<0.05) than animals in the CTL group. The other metabolic parameters, body condition score and milk production were not affected by treatments (P>0.05). The liver functionality index was not affected by treatments (P> 0.05). After the separation of the animals in groups of high and low index of liver function, the animals of the group with better liver function (high) had lower concentrations of beta-hydroxybutyrate (P<0.05) and a trend of lower concentrations of non-esterified fatty acids (P<0.10), whereas the animals with poor liver function (low) showed a tendency to have lower concentrations of albumin (P <0.10). In conclusion, in this study the liver functionality index was not affected by treatments.