Perfil inflamatório clínico periodontal e sistêmico de pacientes hipertensos

Abstract

The aim of this cross-sectional study was to characterize the periodontal condition and systemic inflammatory markers of hypertensive patients. For this, until now, 35 hypertensive patients (case group) and 35 normotensive individuals (control group) were included and underwent to a full-mouth periodontal examination and blood collection. Plasma levels of triglycerides, HDL and LDL cholesterol, C-reactive protein and fibrinogen were laboratory determined. For data analysis, Poisson regression models were used to estimate the association between hypertension and moderate-to-severe periodontitis (CDC/AAP criteria) or periodontal inflammatory conditions. After individuals’ age stratification (<48 or ≥48 years-old), no significant difference in periodontitis prevalence was observed between groups (p>0.05). Similarly, no inter-group differences were observed regarding blood inflammatory markers, irrespective of age strata. Nevertheless, mean values of diastolic pressure, number of obese individuals, mean percentage of gingival inflammation and of bleeding on probing (BOP) were greater in ≥48 years-old hypertensive patients (p<0.05), when compared to normotensive individuals in the same age strata. In adjusted analysis, there was no significant association between hypertension and moderate-to-severe periodontitis. On the other hand, hypertensive patients presented higher chance of have >10% BOP+ sites (OR 2.808; 95%CI 1.39- 5.66) or Periodontal Probing Depth (PPD) ≥4mm sites (OR 1.736; 95%CI 1.01- 3.25) in comparison with normotensive individuals. From these preliminary results, hypertensive patients were associated with the presence of periodontal inflammation clinically relevant. Despite this, it is necessary to complete the protocol of the study to made more precise conclusions can be made, especially controlling for age of the participants.