Síntese de tiocetais utilizando glicerol como solvente reciclável

Abstract

We describe herein the use of glycerol as an efficient and a recyclable solvent in the thioacetalization of aldehydes and ketones. The catalyst-free reactions proceeds easily using glycerol at 90 C and the corresponding thioacetals 3a-n were obtained in good to excellent yields (Scheme 1). Besides, the same procedure was applied for the synthesis of dithiolanes 3o-r by reaction of aldehydes and ketones 1a,j-l with 1,2-ethanedithiol 2c (Scheme 2). Glycerol was recovered and utilized for further thiocetalization reactions