Síntese de sulfetos vinílicos a partir de alquinos terminais utilizando KF/Al2O3 em meio livre de solvente.Síntese de Sulfetos Vinílicos a Partir de Alquinos Terminais Utilizando KF/Al2O3 em Meio Livre de Solvente.

Abstract

Here we present the full results of a new, clean and efficient protocol for the hydrothiolation of alkynes promoted by KF/Al2O3, using PEG-400 as recyclable solvent or solvent-free conditions. This efficient and improved method furnishes selectively the corresponding anti-Markovnikov vinyl sulfides in good to excellent yields starting from terminal alkynes and aliphatic or aromatic thiols. Both, the catalytic system and PEG-400 can be reused up to 2 times without previous treatment with comparable activity