Síntese de 1,3-Tiazolidin-4-Onas derivadas da primaquina: potenciais agentes antimaláricos

Abstract

This work describes the one-pot synthesis of 1,3-thiazolidin-4-ones from antimalarial drug primaquine, arenealdehydes and mercaptoacetic acid. We also used the cyclohexanone as carbonyl precursor to synthesis of spirothiazolidinones. All compounds were purified by column chromatography using a mixture of hexane:ethyl acetate (7:3), identified and characterized by 1H and 13C NMR. In conclusion, seventeen novel thiazolidinones derivatives of primaquine were obtained in moderate to good yields (37-89%) after purification. These heterocycles are potential antimalarial agents and their antimalarial study is ongoing.