Condições da gestação e da infância associadas ao Peptídeo-C e sua atuação sobre componentes do risco cardiovascular em adultos jovens na Coorte de Nascimentos de 1982, Pelotas, RS

Abstract

Cardiovascular diseases are the leading cause of death in the world and their prevalence increases with age and the simultaneity of risk factors. The C-Peptide derived from the enzymatic cleavage of the proinsulin into insulin is secreted in equimolar amounts the same, serving as an indicator of its secretion. The role of C-Peptide has been investigated as a marker of cardiovascular risk in adults. Few studies have evaluated gestational and childhood conditions associated with C-Peptide levels in adulthood. The Pelotas Birth Cohort (RS) has been accompanying, at different moments in the life cycle, individuals born in the city of Pelotas since 1982. In 2004-2005, all cohort participants were monitored through interviews and evaluations When blood samples were taken from 3913 participants. The present work aims to identify the early conditions associated with pregnancy, birth and childhood associated with C-Peptide in adulthood and its possible association with metabolic factors of cardiovascular risk in young adults in the 1982 Birth Cohort, Pelotas; Br.