Síntese de 3-tioidrochalconas através de reações one pot e redução de chalconas utilizando glicerol como solvente

Abstract

In this study 3-thiohydrochalcones were synthesized using KF/Al2O3 as a base and glycerol as a solvent. The methodology proposed is based on the principles of Green Chemistry using one pot procedure from ketones 1, aldehydes 2 and thiols 4. Ten 3- thiohydrochalcones 5 were obtained containing aromatic and aliphatic substituents in good yields. Moreover, it was possible to reduce twelve α,-unsaturated ketones in a similar condition using diphenyl diselenide 6, hypophosphorous acid (H3PO2) and glycerol to form the corresponding saturated ketones 8 in good yields (Scheme 1). It was also possible to reuse the H3PO2/glycerol system without prior treatment while maintaining its efficiency.