Síntese de Arilselanilalquil-1,2,3-triazóis via Cicloadição 1,3-dipolar entre Arilselanilalquinos e Benzilazidas Catalisada por Sais de Cobre.

Abstract

In this work, we describe the use of organic selenium compounds in "Click Chemistry" reactions the copper-catalyzed 1,3-dipolar cycloaddition between arylselanylalkynes and substituted benzyl azides. Under optimized reaction conditions, a variety of benzyl azides 2a-j were converted to arylselanylalkyl-1,2,3-triazoles 3a-j by reaction with (prop-2-yn-1-ylselanyl)benzene 1a. The corresponding products 3a- j were obtained in yields ranging 74-96%. Extending this protocol, the synthesis of arylselanylalkyl-1,2,3-triazoles 3m-s was performed, starting from the benzyl azide 2a and varying the arylselanylalkynes 1b-h, furnishing the desired products in high yields (81 to 90%).