Efeitos da suplementação de curcumina (Curcuma longa) nos marcadores de inflamação, estresse oxidativo e dano muscular induzido pelo exercício físico: uma revisão sistemática e metanálise

Abstract

Curcumin, the main polyphenol found in turmeric (Curcuma longa) has been widely studied for its antioxidant and anti-inflammatory properties, which can help repair oxidative and inflammatory conditions. Knowing that the practice of strenuous physical exercise (high intensity, long duration and/or insufficient rest) can influence immune function, increasing the levels of biomarkers of muscle damage and inflammation, curcumin supplementation could reduce some of the consequences of exercise practice. intense. Thus, the present study investigated the effects of curcumin supplementation on markers of inflammation, oxidative stress and exercise-induced muscle damage. For this, randomized clinical trials conducted in physically active healthy adults of both sexes were selected, which investigated the association between curcumin supplementation and physical exercise. Nine databases were reviewed: PubMed, Embase, Scopus, Sport discus, Cumulative Index of Nursing and Health Literature (CINAHL), Web of Science, Cochrane Central Register of Controlled Trials, ReBEC and Clinical Trials. Data extraction and quality assessment were performed by two reviewers independently. A total of 811 studies were located, however only 16 clinical trials were included. In the qualitative analysis, only five studies reported significant results in the reduction of creatine kinase, two found increased concentrations of interleukin-6, two showed an increase in the total antioxidant capacity and only one observed a reduction in the levels of tumor necrosis factor-α. The results found in the meta-analysis do not indicate a significant association between the use of curcumin and inflammation markers (tumor necrosis factor-α, interleukin-6, interleukin-10), oxidative stress (total antioxidant capacity, superoxide dismutase, glutathione reductase) and muscle damage. exercise induced (creatine kinase, lactate dehydrogenase, myoglobin, transaminases). When assessing the risk of bias of the included studies, only one had low risk, two had high risk, and the others had some limitations. Based on the available evidence, curcumin has no significant effects on reducing muscle damage biomarkers. It is noteworthy that the studies have important limitations, such as different types of exercise, dosage and non-standard population, which can make conclusions about curcumin and physical exercise difficult.