Síntese de bis-4,7-arilsulfenil-benzo-2,1,3-selenadiazóis através de reações de acoplamento cruzado catalisadas por cobre

Abstract

In this work, the synthesis of bis-sulfenyl-benzo-2,1,3-selenadiazoles 3 is described through the reaction of 4,7-dibromoselenadiazole 1 and a range of thiols 2a-j, using dimethyl sulfoxide (DMSO) as solvent, potassium hydroxide (KOH) as base and copper oxide nanoparticles (CuONPs) as catalyst. Through this methodology, a series of bis-4,7-arylsulfenyl-benzo-2,1,3-selenadiazoles 3a-j were synthesized with yields ranging from medium to excellent (55-86%). It is important to note that this methodology was efficient with a range of aryl thiols containing electron donating or withdrawing groups at the benzene ring.