Avaliação metabólica de ruminantes submetidos a diferentes formas farmacêuticas de administração de cálcio e magnésio

Abstract

Milk Fever it is one of the diseases that more attack dairy cows in the transition period, being considered as a “production of disease”, with high economic impact. Given this, was conducted a study, which the aim was evaluate the serum concentration of total calcium (Cat), ionized calcium (Cai), magnesium (Mg) and metabolism the sheep from two pharmaceutical forms the utilization of calcium and magnesium. In this study were used 24 sheep of Corriedale breed, in post-partum, divided into four groups. Previously all the animals were weighted and divided, homogeneously: group intravaginal device DCaMg (polymer-based + calcium formate + magnesium chloride), control device DC (polymer-based), OCaMg (distilled water + calcium formate + magnesium chloride), OC (distilled water). The blood samples were collected at 6 hours at 30 minute intervals and after 12, 24 and 48 hours, for the evaluation of Cat, Mg, total protein (PPT), aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT), urea, creatinine and albumin concentrations. Cai concentrations were estimated by the following formula:(6.Cat (0,19.PPT)+albumin)/3/((0,19.PPT)+albumin+6. To assess the urinary pH for later comparison between the treatments, was realized urine collection at 0, 3, 6 and 12 hours. The serum concentrations of total calcium and ionized calcium of DCaMg group was higher than the DC. The OCaMg and OC did not differ .The DCaMg and OCaMg did not differ. The serum concentrations of Mg of DCaMg group was higher than the DC. Blood levels of Mg in OCaMg and OC did not differ, and the DCaMg did not differ from the OCaMg. Serum concentrations of PPT, AST, GGT, albumin, urea and pH did not differ between groups. Overall, the intravaginal device makes a potential alternative to ensure a considerable bioavailability of calcium and serves as efficient way for prevention and/or hypocalcemia treatment in ruminants.