Chalconas: síntese em glicerina e análise das propriedades antifúngicas e antibacterianas

Abstract

A series of sixteen chalcones was synthesized by Claisen-Schmitd condensation, using glycerin as reaction solvent. The glycerin comprises a renewable solvent, and it is a co-product of biodiesel production. The interesting molecules were obtained in good yields and purity. In microbial assays, the method employed was microdilution, most recommended for these molecules, which were tested in bacterial strains Staphylococcus aureus ATCC19095, Enterococcus faecalis ATCC4083, Escherichia coli ATCC29214 and Pseudomonas aeruginosa ATCC9027 and four strains of yeasts: Candida albicans ATCC 62342and three clinical strains from the human oral cavity of the C. Albicans and stored in mycologycollection. Also, we highlight the 1,3-diphenylprop-2-en-1-one (3a), which showed MIC of 250 µg/mL at C. albicans 1, whereas the fluconazole showed MIC greater than 500 mg/mL; the 3- (4-bromophenyl)-1-(thiophen-2-yl)prop-2-en-1-one (3l) with IC50 13,91 µg/mL in E. faecalis, however, greater than tetracycline and chloramphenicol and the 3-(3- methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one (3p), that showed activity in several bacterias, with IC50 219,1 µg/mL for S. aureus, 441,9 µg/mL for P. aeruginosa and 338,5 µg/mL for E. faecalis.