Síntese verde de 3-Selanilindóis e Benzotiazóis 2-substituídos

Abstract

Considering the relevance of heterocyclic compounds, the development of new general and selective methodologies for the synthesis of these molecules is a relevant topic in organic synthesis. In this work two methodologies were developed for the preparation of two different heterocyclic nucleous. The first study deals with the preparation of 3-selanylindole by reaction of the indole nucleus 1 with different arilselaninic acids 2 in glycerol as solvent (Scheme 1). Nine 3-selanylindoles were prepared in yields of 45-91% in 24 hours of reaction. The second study relates to the preparation of 2-substituted benzothiazoles by cyclization between bis-(2-aminophenyl) disulfide 4, different alcohols 5, in a sealed system using di-tert-butyl peroxide (DTBP) as an oxidant. Ten benzothiazoles with different substituents were prepared in 20-97% redissures after 6 h of reaction at 150 ° C (Scheme 2).