Síntese limpa de 2-(3,5-diaril-4,5-diidro-1H-pirazol-1-IL)-4-feniltiazóis promovida por ultrassom

Abstract

This work describes a rapid and clean procedure for the synthesis of a series of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles under ultrasonic irradiation, from the cyclization of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles and phenacyl bromide. These reactions were carried out in ethanol in periods of reduced time concerning to the methods described in the literature. Were isolated 11 compounds, with good yields (47-93 %) and excellent purities.