Estudo do potencial farmacológico do óleo essencial das folhas da Eugenia uniflora L.

Abstract

Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system’s ability to readily detoxify the reactive intermediates or to repair the resulting damage, and currently is involved in more than 100 diseases. In this way is of great interest the search for new molecules with antioxidant potential, between these researches natural products, especially essential oils stand, like Eugenia uniflora. The E. uniflora essential oil possesses antinociceptive, antibacterial and antifungal activities. The goal of this work was evaluated the antioxidant, antimicrobial, genotoxic, revered effect in a damage caused by acetaminophen and antidepressant effect of the E. uniflora EO. The results demonstrated that this EO present antioxidant effects, reduced lipid peroxidation in liver and brain structures, furthermore the EO was able to reversed the hepatic damage caused by a super dose of acetaminophen and was not genotoxic in blood and marrow cells of mice. The EO presents antidepressant effect with possible involvement of serotoninergic and adrenergic systems. So, in this study the E. uniflora EO possesses pharmacological effects without toxicity. These findings suggest that the EO of the leaves of E. uniflora may have the potential for use in the pharmaceutical industry.