Efeitos crônicos de diferentes modelos de exercício físico sobre a temperatura corporal, parâmetros inflamatórios e de estresse oxidativo em animais submetidos ao lipopolissacarídeo.

Abstract

Aim: To compare the chronic protective effects of different models of physical exercise on body temperature, serum levels of inflammatory cytokines and brain parameters of oxidative stress in C57BL/6 female mice submitted to induction of systemic inflammation by (lipopolysaccharide) LPS. Methods: Animals were divided into three groups: control (sedentary) (n=10), intermittent high intensity exercise (n=10) and continuous moderate intensity exercise (n=10). The training lasted 6 weeks and, seventy-two hours after the last session, a dose of 250 μg/kg of LPS from the bacterium Escherichia coli was injected in the animals. Results: The sedentary group had a decrease in body temperature in the first hour after LPS, remaining low in the following 12 hours [F(3.27)=11.15, p=<0.001], which did not happen in the exercise groups. In addition, the HIIT group had higher values of total thiol content in the hippocampus than the continuous group [F(2.12)=4.52, p = 0.03]. However, exercise models did not exert protective effects on the other oxidative and antioxidant parameters analyzed in the cerebral cortex and hippocampus, as well as on the serum levels of IL-6 and TNF-α. Conclusion: This was the first study to demonstrate that six weeks of moderate continuous training and high intensity interval training were also sufficient to prevent the temperature decrease resulting from the administration of LPS in C57BL / 6 mice, meaning that both are efficient as a form to combat one of the most characteristic symptoms of LPS and, consequently, of gram-negative bacteria infections. In addition, HIIT was sufficient to increase hippocampal antioxidant defenses.