Coagulopatias hereditárias em odontologia: uma análise da evidência científica e geração de conhecimento para aplicação na prática clínica

Abstract

This Ph.D. thesis aimed to analyze the scientific evidence considering patients with Inherited Bleeding Disorders and dental procedures. Inherited bleeding disorders (IBDs) are a heterogeneous group of genetic conditions in which missing or defective clotting factors prevent normal blood clotting from occurring, been Hemophilia A, Hemophilia B, and von Willebrand´s disease the most prevalent. However, the literature is still scarce about the oral health conditions, type of treatment, and particularities regarding these subjects and dentistry. This study presents case reports, one clinical study about the use of dental implants, two scoping reviews (endodontics and oral surgery), and a metaanalysis comparing the caries experience between IBDs and healthy subjects. Thus, the goal of this Ph.D. thesis was to generate evidence, contributing to the scientific field, aiming to reduce postoperative complications after dental procedures in patients with inherited bleeding disorders.