Síntese de Calcogeno Éteres Derivados do Glicerol Utilizando PEG-400

Abstract

In this work, the synthesis of chalcogen ethers 3 from glycerol derivatives was performed by nucleophilic substitution reaction of tosyl group of ketal 1 with diorganoil dichalcogenides 2 using NaBH4 as a reducing agent and PEG-400 (polyethylene glycol) as a green solvent (Scheme 1). The method was simple, general and providing S, Se and Te derivatives in yields moderate to excellent (40 - 96%).