Síntese de compostos 1-fenil-15H-dibenzo [d,h] [1,2,3] triazol [1,5- a] [1,3,6] triazoninas através de reação multicomponente catalisada por CuI

Abstract

In this work we developed a multicomponent method for the synthesis of compounds 1-phenyl-15H-dibenzo[d,h][1,2,3]triazol[1,5-a][1,3,6]triazonines using copper iodide as catalyst. The reaction between 2-azidobenzaldehyde 1, ortho-phenylenediamine 2 and a terminal alkyne 3 occurred at mild condittions, under N2, atmosphere and 100 °C, in the presence of TEA as base, DMSO as solvent and CuI in catalytic amounts of 10 mol%. After 24 hours of reaction, the 1-phenyl-15H-dibenzo[d,h][1,2,3]triazol[1,5-a] [1,3,6] triazonines compounds 4 were obtained with 45-98% yields.